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  • Title: Hyperglycaemia and survival after haemorrhage.
    Author: Ljungqvist O, Alibegovic A.
    Journal: Eur J Surg; 1994 Sep; 160(9):465-9. PubMed ID: 7849164.
    Abstract:
    OBJECTIVE: To assess the relation between the degree of hyperglycaemia during a standard haemorrhage and survival. DESIGN: Prospective laboratory study SETTING: University department of surgery, Sweden MATERIAL: 5 groups of 8-12 adult male Sprague-Dawley rats. INTERVENTIONS: Different degrees of hyperglycaemia were achieved in the 5 groups of rats (which had been starved for 24 hours) by infusion of the same amount of 0.9% saline, or 5%, 10%, 20% or 30% glucose during a 48% standard haemorrhage over 60 minutes. Blood glucose concentration and packed cell volume were measured every 30 minutes, and mean arterial pressure was monitored constantly. MAIN OUTCOME MEASURE: Survival at 7 days. RESULTS: Increases in blood glucose concentrations during haemorrhage correlated with plasma refill as indicated by reductions in packed cell volume (r = 0.85, p < 0.0001). Both increases in blood glucose concentrations and reductions in packed cell volume were inversely related to blood pressure during haemorrhage (p < 0.0001). The more glucose that was infused, the higher the blood glucose concentration and the better the plasma refill during haemorrhage which correlated with improvement in the rate of survival at 7 days (p < 0.001). CONCLUSION: The ability to mount a hyperglycaemic response is an important prognostic factor in survival after experimental haemorrhage.
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