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  • Title: Origin and molecular epidemiology of penicillin-binding-protein-mediated resistance to beta-lactam antibiotics.
    Author: Dowson CG, Coffey TJ, Spratt BG.
    Journal: Trends Microbiol; 1994 Oct; 2(10):361-6. PubMed ID: 7850202.
    Abstract:
    Resistance to beta-lactam antibiotics in some naturally transformable bacterial pathogens has arisen by interspecies recombinational events that have generated hybrid penicillin-binding proteins with reduced affinity for the antibiotics. This type of resistance is of particular concern in pneumococci, in which it is increasing worldwide.
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