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  • Title: Mutagenic and carcinogenic risk of oxygen containing chlorinated C-3 hydrocarbons: putative secondary products of C-3 chlorohydrocarbons and chlorination of water.
    Author: Eder E, Weinfurtner E.
    Journal: Chemosphere; 1994; 29(9-11):2455-66. PubMed ID: 7850393.
    Abstract:
    Oxygen containing C-3 chlorohydrocarbons are secondary products of C-3 chlorohydrocarbons formed during oxidation at air, in the metabolism of pesticides and by chlorination of drinking water. These compounds are mutagenic, genotoxic and carcinogenic. 2-Chloroacroleins are extremely strong mutagens and genotoxins and form 1,N2-cyclic deoxyguanosine adducts. The role of such adducts in mutagenicity and carcinogenicity is discussed.
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