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  • Title: Regional immunotherapy with intrapleural BCG for lung cancer.
    Author: McKneally MF, Maver C, Kausel HW, Alley RD.
    Journal: J Thorac Cardiovasc Surg; 1976 Sep; 72(3):333-8. PubMed ID: 785107.
    Abstract:
    A living vaccine, the bacille Calmette Guérin (BCG) strain of Mycobacterium tuberculosis bovis, has been administered in a single postoperative intrapleural dose as a controlled equivalent of postoperative empyema in 38 patients following pulmonary resection for lung cancer. This form of regional immunotherapy is reasonably well tolerated if the vaccine is given in a limited dose and if a follow-up course of isoniazid (INH) is administered. In this report, the technical details of this new therapeutic program are reviewed. The preliminary findings in a randomized prospective clinical train of the technique indicate that patients with Stage I lung cancer are significantly benefitted by the treatment. Patients with more advanced disease are unimproved by this form of therapy.
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