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  • Title: Sustained release metoclopramide for prophylaxis of post-operative nausea and vomiting.
    Author: Elliott RH, Graham SG, Curran JP.
    Journal: Eur J Anaesthesiol; 1994 Nov; 11(6):465-7. PubMed ID: 7851353.
    Abstract:
    Oral metoclopramide may be given as a premedicant to reduce post-operative nausea and vomiting, but there is little evidence that it is effective. We studied the anti-emetic action of a sustained release formulation of metoclopramide (Gastromax 30 mg) in 39 fit women undergoing inpatient laparoscopy under general anaesthesia with a standardized anaesthetic technique in a double-blind placebo-controlled trial. No benefit was demonstrated. (Incidences: nausea: 13 of 20 patients [placebo] and 13 of 19 [metoclopramide]; vomiting: 13 of 20 and 12 of 19.)
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