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  • Title: Rifampicin-induced protein synthesis: A pre-requisite for increased expression of the beta beta' operon in Escherichia coli.
    Author: Tittawella PB.
    Journal: Mol Gen Genet; 1976 Jul 05; 146(1):79-83. PubMed ID: 785212.
    Abstract:
    In a rifS/rifR heterodiploid strain of E. coli, a 4 minute pulse of rifampicin can induce a prolonged (greater than 60 min) increase in the rate of synthesis of the RNA polymerase subunits, beta and beta'. The application of a constraint on the fidelity of protein synthesis during, but not after, the rifampicin pulse partially arrests the development of this capacity for subunit synthesis. I discuss the implications of these findings in relation to the control of the BB' operon in E. coli.
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