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  • Title: Fate of etiproston, a synthetic analogue of PGF2 alpha, in cows.
    Author: Benech H, Brune P, Pruvost A, Archimbault P, Guillot P, Murphys RC, Maclouf J, Grognet JM.
    Journal: J Vet Pharmacol Ther; 1994 Oct; 17(5):339-44. PubMed ID: 7853457.
    Abstract:
    The pharmacokinetics and metabolic fate of labelled compounds were investigated after intramuscular administration of 3H-radiolabelled etiproston to nine cows. Elimination was rapid (t 1/2 beta = 2.8 h). Forty-eight h after administration 92.6% of the radioactivity had been eliminated, mainly via the urinary (66% at 48 h) and faecal routes (26% at 48 h). In comparison, little elimination in milk occurred (less than 0.034% dose/l by 24 h). Radioactivity at the injection site 48 h after administration was seen in one cow (< 4.68 x 10(-5%) dose/g). No radioactivity was detected in the tissues. Urinary metabolites were purified and isolated using XAD-2 extraction and preparative HPLC in reverse and normal phases. The main urinary metabolite, identified by mass spectrometry, was the tetranor acid derivative in equilibrium with its lactone form.
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