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  • Title: Immunologic reconstitution in severe combined immunodeficiency following transplantation with parental bone marrow.
    Author: Geha RS, Malakian A, LeFranc G, Chayban D, Serre JL.
    Journal: Pediatrics; 1976 Sep; 58(3):451-5. PubMed ID: 785357.
    Abstract:
    A 9-month-old girl with severe combined immunodeficiency was transplanted with BM cells from her father. The child had complete restoration of cell-mediated immune functions. Humoral immune functions remain absent nine months after transplant. Child and father were HL-A identical and their lymphocytes were nonreactive in mixed lymphocyte culture. The parents of the child were first cousins and shared an HL-A haplotype. In countries like Lebanon, where there is a high incidence of first-cousin marriages (15%) and where villages are relatively isolated, the search for histocompatible graft donors should extend beyond the siblings to other members of the family.
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