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  • Title: A case of primary glomerular fibrosis associated with the accumulation of type I and type III collagen.
    Author: Ozu H, Nitta K, Yumura W, Horita S, Honda K, Nihei H.
    Journal: Nihon Jinzo Gakkai Shi; 1994 Nov; 36(11):1315-9. PubMed ID: 7853766.
    Abstract:
    A 49-year-old woman suffering from nephrotic syndrome (NS) was admitted for renal biopsy and treatment of NS. Light microscopy demonstrated that the glomerular capillary wall was markedly thickened with diffuse accumulation of periodic acid Schiff- and periodic acid methenamine-positive materials, leading to lobular accentuation of glomerular tufts. By electron microscopy, numerous collagenous fibers were observed in the mesangium and subenodothelial area. The fibers were peculiarly curved and frayed, as reported in nail-patella syndrome. These materials were thought to be type I and type III collagen as a result of immunohistochemical studies. No laboratory data or pathological findings were found to be compatible with previously described glomerulonephritis. The primary glomerular fibrosis in the present patient seemed to be a case of collagenofibrotic glomerulonephropathy.
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