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  • Title: Biochemical analysis of breast cyst fluid as a possible predictor of breast carcinoma development.
    Author: Simíøcková M, Pecen L, Eben K, Nekulová M, Vermousek I, Stratil P, Rejthar A, Cernoch M, Lang B, Sakalová J.
    Journal: Neoplasma; 1994; 41(5):245-52. PubMed ID: 7854493.
    Abstract:
    The occurrence of breast cancer in patients with gross cystic disease is 2-5 times higher as compared to control group of women. During 3 years, 183 cyst fluid samples were analyzed in 129 females, in 30 patients of them the samples were analysed repeatedly. The distribution of the Na+/K+ ratio, considered as the measure of cancer risk, was found to be bimodal. In repeated analyses the type I cyst fluid markedly predominated (Na+/K+ < or = 4.0). A direct dependence on this ratio was found in the concentration of glucose, albumin, carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA) and its specific form, TPS; an indirect dependence was found for the level of uric acid, phosphates, alkaline phosphatase (ALP) and alpha-amylase (AMS). The predominance of apocrine metaplasia cells released into the cyst fluid is characteristic of type I cysts. A definitive assessment of significance of these parameters will be enabled by a long-term follow-up of the disease in the respective patients.
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