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  • Title: [Changes in the immunobiochemical composition of the cerebrospinal fluid and the antitumor reactions of the local immune system in astrocytic brain tumors].
    Author: Khil'ko VA, Khlunovskiĭ AN, Starchenko AA, Komarets SA, Lushnov MS.
    Journal: Zh Nevrol Psikhiatr Im S S Korsakova; 1994; 94(4):36-9. PubMed ID: 7856374.
    Abstract:
    Pre- and postoperative immunochemical indices of cerebrospinal fluid (CSF) were investigated in 10 patients with fibrillary-protoplasmic astrocytoma and 10 patients with glioblastoma multiforme. Malignant neoplastic developments in the brain are associated with appearance of marked humoral reaction. Tumor-specific CSF changes observed comprise registration of ceruloplasmin immunomodulating proteins and alpha 2-macroglobulin. It is emphasized that biochemical antioxidant, antiprotease, energy-supplying systems are related directly to humoral immune reactions in the process of relevant postoperative rehabilitation.
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