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  • Title: Leptomeningeal carcinomatosis: review of the literature.
    Author: Iaconetta G, Lamaida E, Rossi A, Signorelli F, Manto A, Giamundo A.
    Journal: Acta Neurol (Napoli); 1994 Aug; 16(4):214-20. PubMed ID: 7856476.
    Abstract:
    Metastases from solid tumors that seed the leptomeninges (meningeal carcinomatosis) are an important neurologic complication of systemic cancer. Recently many authors have reported that its incidence is increasing; particularly it has been demonstrated for breast cancer and small cell bronchogenic carcinoma. A cytologic examination of cerebrospinal fluid (CSF) establishes the diagnosis. Gadolinium-enhanced MRI has demonstrated superiority over other imaging with the clinical context and CSF analysis may lead to a rapid diagnosis and treatment of leptomeningeal carcinomatosis. Despite all measures, prognosis remains poor because of the presence of multiple metastases elsewhere.
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