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  • Title: [Effect of intraperitoneal chemotherapy with implantable reservoir against unresectable gastric cancer].
    Author: Kawasaki S, Nagai K, Maruyama S, Murakami M, Yosizane K, Morokoshi Y, Kawai K, Yamamoto M, Soda M, Misumi T.
    Journal: Gan To Kagaku Ryoho; 1995 Feb; 22(2):215-20. PubMed ID: 7857095.
    Abstract:
    Intraperitoneal chemotherapy was applied for eight unresectable gastric cancer patients, including two exploratory laparotomy and six gastrojejunostomy. Chemotherapeutic agents were given ip at a dose of 75 mg/body of cisplatin and 150 mg/body etoposide and iv at a dose of 10 mg/body of mitomycin C as well as orally 5-FU. This treatment was repeated three to ten times. An overall response rate against primary lesion was 40%. Six month and 1 year survival rate of this therapy were 87.5% and 75% respectively, while those of control group were 42% and 0%. Median duration of survival was 518 days in this chemotherapy group and 172 days in the control. In this study, intraperitoneal chemotherapy group showed a significant improvement of survival compared to the control. All patients were able to stay home between therapies. This method seemed to be beneficial to the unresectable gastric cancer patients.
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