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Title: Genotoxicity testing of pidotimod in vitro and in vivo. Author: Adams K, Allen JA, Brooker PC, Henderson L, Jones E, Proudlock RJ, Mailland F, Coppi G. Journal: Arzneimittelforschung; 1994 Dec; 44(12A):1454-9. PubMed ID: 7857341. Abstract: The mutagenic potential of pidotimod ((R)-3-[(S)-(5-oxo-2- pyrrolidinyl)carbonyl]-thiazolidine-4-carboxylic acid, PGT/1A, CAS 121808-62-6) was assessed in a series of five assays designed to measure gene mutation, chromosomal damage and primary DNA damage. All tests were carried out in accordance with appropriate EEC and OECD Guidelines. No indications of mutagenic potential were observed in any of the assays.[Abstract] [Full Text] [Related] [New Search]