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  • Title: Pharmacokinetics of pidotimod in elderly volunteers and in renal failure patients.
    Author: Spotti D, Biffi M, Coppi G, Silingardi S, Mailland F.
    Journal: Arzneimittelforschung; 1994 Dec; 44(12A):1470-2. PubMed ID: 7857344.
    Abstract:
    The pharmacokinetics of pidotimod ((R)-3-[(S)-(5-oxo-2-pyrrolidinyl) carbonyl]-thiazolidine-4-carboxylic acid, PGT/1A, CAS 121808-62-6) in elderly volunteers and in patients with renal failures were investigated. No differences in absorption, excretion and pharmacokinetic parameters was evident between old volunteers and the youngs of a previous work. Patients with impaired renal function showed different pharmacokinetic parameters of pidotimod in relation to different grade of kidney function. There were linear relationships between elimination half-lives and plasma levels of creatinine and urea; longer half-lives correspond to higher levels of creatinine and urea. As the half-life of the compound did never exceed 8-9 h, the data do not support any change of pidotimod administration schedule (every 24-12 h).
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