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  • Title: Modulation of cytokine expression by hypericum extract.
    Author: Thiele B, Brink I, Ploch M.
    Journal: J Geriatr Psychiatry Neurol; 1994 Oct; 7 Suppl 1():S60-2. PubMed ID: 7857513.
    Abstract:
    The effect of hypericum extract LI 160 on the stimulated cytokine expression was investigated in vitro in a whole blood culture system. Blood samples were taken from five healthy volunteers and four depressive patients. The release of interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) was measured quantitatively after an incubation time of 24 hours on microtiter plates. A massive suppression of the interleukin-6 release was found for PHA-stimulated hypericum extract. Possible relations to the antidepressive effects of hypericum extract are discussed.
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