These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Gonadotropin releasing hormone test: diagnostic significance and limits in menstrual pathology.
    Author: Venturoli S, Nardi M, De Aloysio D, Magrini O, Flamigni C.
    Journal: Acta Eur Fertil; 1976 Mar; 7(1):1-38. PubMed ID: 785926.
    Abstract:
    The serum gonadotropin response to LH-RH (100 mug e.v.) in a group of women with various types of amenorrhea was critically evaluated. Most patients responded to rapid LH-RH injection with a significant rise in plasma LH and FSH. In the authors' opinion this response is observed in healthy women as well as in those with lesions, even severe ones, of the pituitary, so that quantification of the response does not supply reliable information on diagnosis and prognosis. On the other hand, a negative response to the injection of 100 mug LH-RH does not necessarily imply a pituitary lesion but is often a sign of altered hypothalamic function which can be diagnosed and in some instances restored by clomiphene administration. The diagnostic significance and limits in menstrual pathology of the gonadotropin releasing hormone (Gn-RH) test were evaluated. Subjects consisted of 10 women with regular ovulatory cycles and 82 women with anovulatory cycles for a variety of reasons. Basal levels of gonadotropin and 17beta-estradiol were determined. Subjects were tested using a 100 mcg dose of synthetic Gn-RH and blood was drawn after 10, 20, 30, 60, 90, 120 minutes and 9 and 24 hours later for the assay of luteinizing hormone (LH), follicle stimulating hormone (FSH), and 17beta-estradiol. Most patients responded to rapid Gn-RH injection with a significant rise in plasma LH and FSH. This response was observed in healthy women as well as in those with lesions. Quantification of the response is an unreliable source of information on diagnosis and prognosis. A negative response to the injection may imply an altered hypothalamic function which can be diagnosed and perhaps restored by clomiphene administration, rather than implying a pituitary lesion.
    [Abstract] [Full Text] [Related] [New Search]