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  • Title: [Double-blind comparative study on the effects of lofepramine and amitriptyline in depressive outpatients (author's transl)].
    Author: Wright S, Herrmann L.
    Journal: Arzneimittelforschung; 1976; 26(6):1167-9. PubMed ID: 786313.
    Abstract:
    The anticholinergic side-effects of tricyclic antidepressants are unpleasant for the patients. Lofepramine, a new tricyclic antidepressant, has in animal studies been shown to have weak anticholinergic effects and a low acute toxicity. The aim of the present study was to see whether these pharmacological properties led to a lower rate of side-effects in depressed patients. In a double-blind trial 40 outpatients were treated with lofepramine or amitriptyline. Assessments were made with the Hamilton Scale, the Wakefield Self-Assessment Scale and a Side-effect Scale. 33 patients completed the trial. Both drugs proved effective. There were small differences in favour of lofepramine both in therapeutic efficacy and frequency of side-effects.
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