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  • Title: Penicillin susceptibility testing of penicillinase producing Neisseria gonorrhoeae by the E test: a need for caution.
    Author: Young H, Moyes A, Hood A.
    Journal: J Antimicrob Chemother; 1994 Oct; 34(4):585-8. PubMed ID: 7868410.
    Abstract:
    The penicillin MICs of 52 clinical isolates of penicillinase producing Neisseria gonorrhoeae (PPNG) and five reference strains were tested by agar dilution and the E test. All 52 PPNG were scored resistant (> or = 2 mg/L) by agar dilution whereas only 78.8% (41/52) and 82.7% (43/52) were classified as resistant by normal (0.016-256 mg/L) and low range (0.002-32 mg/L) E test MICs respectively. Isolates with an E test penicillin MIC > or = 0.19 mg/L should be checked by a specific test for beta-lactamase production.
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