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  • Title: Measurement of serum Lp(a) by COBAS MIRA using a latex immunoturbidimetric assay kit.
    Author: Fujita S, Sano T, Katayama Y.
    Journal: J Clin Lab Anal; 1994; 8(6):385-90. PubMed ID: 7869177.
    Abstract:
    We had an opportunity to test a reagent kit for serum lipoprotein (a) [Lp(a)] assay, which was based on the latex immunoturbidimetric assay method, and applied it to COBAS MIRA (Roche). Reproducibility of the assay procedure was 0.92-4.0% CV of three samples which contained 12.58-60.4 mg/dl of Lp(a). Minimum detectable concentration was 1.5-2.0 mg/dl. It was confirmed that interference of co-existing substances, i.e. hemoglobin, bilirubin, and intralipid, was negligible. No cross reactivity was seen with plasminogen. Correlation with a ELISA method was excellent. Frequency distribution of Lp(a) in healthy Japanese was similar to that found in white population.
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