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  • Title: Varied value of urinary N-acetyl-beta-D-glucosaminidase isoenzyme B in males of reproductive age.
    Author: Itoh Y, Numata Y, Morita A, Asano Y, Kawai T.
    Journal: Kidney Int Suppl; 1994 Nov; 47():S38-42. PubMed ID: 7869670.
    Abstract:
    A reliable enzyme-linked immunosorbent assay designed to detect N-acetyl-beta-D-glucosaminidase isoenzyme B (NAG-B) was used to determine distribution and variation of urinary NAG-B in normal and pathologic urine. NAG-B values varied over a much broader range in urine from male than in that from female subjects under different conditions of sampling. Because NAG-B values are markedly high in the semen (5800.2 micrograms/liter on the average), contamination of the urine with NAG-B from genital tissues occurs at urination, when it enters urine containing NAG-B of renal origin. The clinical significance of NAG-B and total NAG enzymatic activity as a renal tubular marker should be carefully evaluated when analyzing urine of males from reproductive age.
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