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  • Title: Antiinflammatory drugs and gastrointestinal bleeding: a comparison of aspirin and ibuprofen.
    Author: Schmid FR, Culic DD.
    Journal: J Clin Pharmacol; 1976; 16(8-9):418-25. PubMed ID: 787015.
    Abstract:
    Gastrointestinal blood loss provoked by short-term and long-term therapy with aspirin and ibuprofen was compared in patients with rheumatoid arthritis. Blood loss was assessed by isotope counting of four-day stool collections after infusion of 51Cr-labeled autologous erythrocytes. After two weeks on drug or after one year on drug, aspirin consistently caused more bleeding than ibuprofen.
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