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  • Title: Blood levels of mianserin and amitriptyline and clinical response in aged depressed patients.
    Author: Monteleone P, Fabrazzo M.
    Journal: Pharmacopsychiatry; 1994 Nov; 27(6):238-41. PubMed ID: 7870745.
    Abstract:
    Steady-state plasma levels of mianserin, amitriptyline, and nortriptyline were determined by HPLC in two groups of elderly depressed patients who underwent a 5-week treatment with mianserin (60 mg/day in three oral doses) or amitriptyline (75 mg/day in three oral doses). Both treatments proved to be effective in reducing depressive symptoms. In the mianserin group, responder patients had steady-state plasma concentrations of mianserin higher than nonresponders. No relationship was found between amitriptyline, nortriptyline, or amitriptyline+nortriptyline plasma levels and clinical response in amitriptyline treated patients.
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