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  • Title: [The effect of Sindbis virus multiplication on gene expression of host cells].
    Author: Wang X, Xie J, Xu X, Liang F, Ding M.
    Journal: Wei Sheng Wu Xue Bao; 1994 Oct; 34(5):345-54. PubMed ID: 7871779.
    Abstract:
    Sindbis virus (SBV) infection mediated a rapid shutoff of host cellular gene expression (mRNA synthesis and protein synthesis); however the synthesis of cellular rRNA remained at the same level as the uninfected cells. Meanwhile a cellular protein P105 was shown to be enriched in the nuclear matrix. Actionmycin D treatment after virus infection resulted in an apparent reduce in the production of viral structural proteins and infectious virions. The results presented here not only demonstrated the complexity of SBV-mediated regulation of host gene expression, but also suggested SBV nonstructural protein nsP2 and capsid protein C were possibly involved in this process.
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