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  • Title: [Therapy of generalized tendomyopathy (fibromyalgia) caused by blocking 5-HT3 receptors].
    Author: Stratz T, Schochat T, Hrycaj P, Lacki J, Mennet P, Färber L, Schweiger C, Müller W.
    Journal: Z Rheumatol; 1994; 53(6):335-8. PubMed ID: 7871905.
    Abstract:
    In more than 40% of patients with fibromyalgia a marked influence on the pain in the skeletal system with a decrease of the tenderness at "tenderpoints" can be achieved by blocking the 5-HT3-receptors with ondansetron or tropisetron-hydrochloride. Physical complaints and vegetative signs also improve. It is discussed if patients not responding to therapy with ondansetron or tropisetron-hydrochloride have to be discriminated as a subgroup of fibromyalgia. More investigations are needed to confirm the described effects.
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