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  • Title: [Incidence of acral nodulosis with long-term methotrexate therapy in patients with inflammatory rheumatic diseases].
    Author: Wagener P.
    Journal: Z Rheumatol; 1994; 53(6):346-50. PubMed ID: 7871907.
    Abstract:
    The significance of acral nodulosis under methotrexate therapy is still controversial. Among patients with rheumatoid arthritis and methotrexate therapy this manifestation could be observed in 8/163 (5%). All cases were seropositive and already treated with other LAAD. Patients with other inflammatory rheumatic diseases under methotrexate therapy (n = 83) did not develop this nodulosis. The acral nodulosis is interpreted as a typical side-effect of methotrexate only in patients with rheumatoid arthritis. Histopathologically, these nodules do not differ from the typical rheumatoid nodule.
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