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  • Title: [Increased viability of skin flaps using naftidrofuryl. An experimental study in the Wistar rat].
    Author: Cothier-Savey I, Mimoun M, Baux S.
    Journal: Ann Chir Plast Esthet; 1994 Apr; 39(2):245-50. PubMed ID: 7872643.
    Abstract:
    The effect of a vasodilator (naftidrofuryl) was evaluated in an experimental study in rats concerning the viability of a skin flap. The reference flap is a dorsal skin flap deliberately shaped very long in order to obtain necrosis of its distal extremity. This necrosis is measurable and sufficiently reproducible. Using a comparative study between a control group of ten rats and a group of rats treated by intraperitoneal injections of naftidrofuryl for ten days, the authors demonstrated a significant difference between necrosis in the two groups. Naftidrofuryl treatment increases the length of the viable part of the skin flap in rats. This product achieves a kind of medicinal autonomy much easier than a surgical autonomy.
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