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  • Title: Effects of 5-fluorouracil derivatives on papillomas induced by application of 7,12-dimethylbenz(a)anthracene in mice.
    Author: Sakamoto S, Matsubara M, Kudo H, Suzuki S, Liu L, Nakayama T, Mitamura T, Nagasawa H.
    Journal: Anticancer Res; 1994; 14(6B):2515-9. PubMed ID: 7872675.
    Abstract:
    We examined the effects of an application of 5-fluorouracil (5-FU) ointment and a chronic oral administration of 1-(2-tetrahydrofuryl)-5-FU plus uracil (UFT) on 7,12-dimethyl-benz(a)-anthracene-induced squamous cell papillomas in mice. Although application of 5-FU ointment reduced the growth of papillomas slightly, chronic oral administration of UFT could prevent tumorigenesis and suppress the growth of papillomas, resulting in the reduction of the tumorous viability and DNA synthesis.
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