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  • Title: [Effect of inductors of alkali cation permeability on cytochrome c bound to mitochondrial membrane].
    Author: Shol'ts KF, Solovbeva NA, Shul'gin MN, Kotel'nikova AV.
    Journal: Biokhimiia; 1978 Jun; 43(6):1012-8. PubMed ID: 78730.
    Abstract:
    The effect of inductors of alkali cation permeability--valinomycin, gramicidin A, gramicidin S and its N,N'-diacetyl derivative--on rat liver mitochondria during respiration has been studied. It is shown that valinomycin, gramycidin A and diacetylgramicidin S at optimal concentration for uncoupling cause two-phase activation of mitochondrial respiration and that this effect results from cytochrome c solubilization. Gramicidin S at optimal concentration cannot remove cytochrome c from the respirating mitochondria. It is suggested that this property of gramicidin S is owned to cytochrome c immobilisation in membrane, due to the effect of this compound.
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