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  • Title: Value of monoclonal antibody-based assays: advantages and drawbacks.
    Author: van Ree R.
    Journal: Arb Paul Ehrlich Inst Bundesamt Sera Impfstoffe Frankf A M; 1994; (87):127-35; discussion 136-9. PubMed ID: 7873051.
    Abstract:
    Monoclonal antibodies (mAbs) directed to allergens are highly specific tools in allergen standardization and quantification. Their mono-specificity allows sensitive detection of individual allergens. It is the same quality that asks for caution. MAbs can be too specific: isoforms of allergens can be missed. On the other hand, mono-specific antibodies can also be crossreactive, possibly resulting in overestimation of allergen content. Lower affinity of mAbs compared to IgE may lead to underestimation of the IgE-binding capacity of an allergen extract. For application of mAbs these potential pitfalls should be taken into consideration.
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