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  • Title: Repeated amphetamine evokes biphasic alterations in the tyrosine hydroxylase mRNA level in the rat adrenal medulla: an in situ hybridization study.
    Author: Jaworska L, Budziszewska B, Lasoń W.
    Journal: J Neural Transm Gen Sect; 1994; 97(2):87-91. PubMed ID: 7873126.
    Abstract:
    In the present study we estimated the effects of single and repeated administration of d-amphetamine (5 mg/kg, i.p., twice a day for 14 days) on tyrosine hydroxylase (TH) mRNA levels in the rat adrenal medulla. In situ hybridization experiments, conducted using a [35S]d-ATP-labelled deoxyoligonucleotide probe and a densitometric analysis of autoradiograms, showed that repeated d-amphetamine moderately increased the TH mRNA level (by ca. 24%) in the adrenal medulla at 2 h after the last injection. In contrast, after 48 h the TH mRNA level was decreased (by ca. 21%). No significant changes in the TH mRNA level in the adrenal medulla were found following single administration of d-amphetamine. These results suggest that repeated d-amphetamine administration leads to biphasic changes in the adrenal TH biosynthesis, which may reflect an adaptive response to chronic drug treatment.
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