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  • Title: [Prevention of cancer recurrence by infusion of activated autologous lymphocytes].
    Author: Sekine T, Takayama T, Konomi Y, Kakizoe T.
    Journal: Hum Cell; 1994 Sep; 7(3):121-4. PubMed ID: 7873494.
    Abstract:
    Activated and expanded autologous peripheral blood lymphocytes by cultivation with immobilized anti-CD3 antibody and IL-2 have been infused to the patients with hepatocellular carcinoma after culative operation as a randomized clinical trial. This study is on-going and primary efficacy endpoints of this study were disease-free survival and overall survival, and the sample size for the study was designed as a minimum of 146 patients. From interim analysis at the second year from start of the study, Eligible cases were 101, 49 cases in treated group and 52 cases in control. Recurrences were confirmed 13 cases from treated group and 22 cases from control group. Minor adverse reaction were observed in 28 cases (57%).
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