These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Action potential-induced quantal secretion of catecholamines from rat adrenal chromaffin cells.
    Author: Zhou Z, Misler S.
    Journal: J Biol Chem; 1995 Feb 24; 270(8):3498-505. PubMed ID: 7876083.
    Abstract:
    Using single rat adrenal chromaffin cells, we examined the coupling of action potential activity to quantal release of catecholamines by combining perforated patch current-clamp recording with electrochemical microcarbon fiber amperometry. Chromaffin cells display steeper dependence of quantal release on action potential frequency than many nerve terminals, as well as more desynchronized release following an action potential. Also in contrast to neurons, in chromaffin cells, a major chemical secretagogue (acetylcholine) triggers potent quantal release even in the absence of electrical activity. These findings are consistent with an hypothesis that a major component of exocytosis from chromaffin cells involves diffusion of Ca2+ to secretion sites which are less well co-localized with Ca2+ channels than those in nerve terminals.
    [Abstract] [Full Text] [Related] [New Search]