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  • Title: Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases.
    Author: Liblau RS, Singer SM, McDevitt HO.
    Journal: Immunol Today; 1995 Jan; 16(1):34-8. PubMed ID: 7880387.
    Abstract:
    CD4+ T cells play a key role in regulating immune system function. When these regulatory processes go awry, organ-specific autoimmune diseases may develop. Here, Roland Liblau, Steven Singer and Hugh McDevitt explore the thesis that a particular subset of CD4+ T cells, namely T helper 1 (Th1) cells, contributes to the pathogenesis of organ-specific autoimmune diseases, while another subset, Th2 cells, prevents them.
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