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  • Title: Prevention of nausea and vomiting with transdermal hyoscine in adults after middle ear surgery during general anaesthesia.
    Author: Honkavaara P, Saarnivaara L, Klemola UM.
    Journal: Br J Anaesth; 1994 Dec; 73(6):763-6. PubMed ID: 7880660.
    Abstract:
    In a double-blind, randomized study, we have compared the efficacy of transdermal hyoscine in the prevention of nausea and vomiting with placebo in 60 young, ASA I-II patients after middle ear surgery during general anaesthesia. In the placebo group, 27% and 43% of patients suffered from nausea and vomiting, respectively, during the first 24 h after anaesthesia. The corresponding values for both symptoms in the hyoscine group were 10% (P < 0.001 between groups). The frequency of side effects was similar in both groups. The results suggest that transdermal hyoscine is a useful prophylaxis against nausea and vomiting after middle ear surgery.
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