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  • Title: Transfer of fat-soluble vitamins and PCBs from mother to pups in grey seals (Halichoerus grypus).
    Author: Schweigert FJ, Stobo WT.
    Journal: Comp Biochem Physiol C Pharmacol Toxicol Endocrinol; 1994 Oct; 109(2):111-7. PubMed ID: 7881814.
    Abstract:
    Lactation in seals is characterized by a rapid and enormous lipid transfer from mother to pups within a milk rich in lipids. Since grey seals do not feed during lactation, all milk constituents are solely derived from body stores. Monitoring levels of fat-soluble vitamins as well as PCBs in blubber and milk may give an insight into the mechanisms involved in their mobilization from blubber, transfer into milk and deposition in the blubber of pups. During lactation, total lipids in milk increased from 261 to 601 g/l. While the level of PCBs in milk per g lipid remained constant throughout lactation, vitamin E, as well as vitamin A and cholesterol, showed a marked decrease during lactation when expressed as quantity per unit lipid. An incomplete transfer of all components from maternal blubber to milk was observed, except for vitamin E. The milk of pregnant females had vitamin E levels per unit which were three times higher than that in blubber, indicating a mobilization of vitamin E from the liver. During the later stages of lactation, there were no differences between the levels of vitamins A and E per unit lipid in the milk and the blubber of suckling pups. The close correlation of PCBs with total milk lipids and the drastic decrease in all other monitored fat-soluble components in seal milk with the progress of lactation point to different mechanisms of mobilization and transport for triglycerides and PCBs compared to fat-soluble vitamins and cholesterol.
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