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  • Title: SCID-Hu mouse as a model for human lung HIV-1 infection.
    Author: Cesbron JY, Agut H, Gosselin B, Candotti D, Raphaël M, Puech F, Grandadam M, Debré P, Capron A, Autran B.
    Journal: C R Acad Sci III; 1994 Jul; 317(7):669-74. PubMed ID: 7882151.
    Abstract:
    HIV induces a multi-organ infection with a dual tropism for both lymphocytes and monocytes/macrophages. The lung is a target both for HIV infection and HIV-related opportunistic infections. The SCID mouse has provided the opportunity to develop a small animal model for HIV infection. However, HIV-1 infection of the human fetal thymus and liver (SCID Liv/Thy) implanted in these mice occurred only after direct intraimplant injection of HIV-1 and the resultant HIV-1 infection was restricted to the human thymus. Here we report that human foetal lung can develop in SCID Liv/Thy mice resulting in the development of normal human alveolar and bronchiolar lung compartments which can be productively infected with cell-free HIV-1 virus, leading to a systemic and bifocal infection. This SCID-Hu model should be useful for studying AIDS physiopathology, human viruses with lung tropism and for helping to define gene therapy protocols in lung human cells in vivo.
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