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  • Title: Hepatic function tests in children with sickle cell anaemia during vaso occlusive crisis.
    Author: Ojuawo A, Adedoyin MA, Fagbule D.
    Journal: Cent Afr J Med; 1994 Dec; 40(12):342-5. PubMed ID: 7882414.
    Abstract:
    Thirty children with sickle cell anaemia had their serum alanine aminotransferase, alkaline phosphatase, total protein, albumin and bilirubin, assayed during vaso-occlusive crisis and at recovery. Alanine aminotransferase, alkaline phosphatase and bilirubin levels were significantly higher during crisis than at recovery, (p < 0.005) especially in the young patient. However, the total protein and albumin levels were not significantly different in crisis and at recovery. A transient hepatic functional derangement during vaso-occlusive crisis is a probable explanation for the reported changes.
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