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  • Title: [Acute psychosis and vigabatrin in childhood].
    Author: Chiaretti A, Castorina M, Tortorolo L, Piastra M, Polidori G.
    Journal: Pediatr Med Chir; 1994; 16(5):489-90. PubMed ID: 7885961.
    Abstract:
    Vigabatrin is an irreversible inhibitor of gamma-aminobutyrate (Gaba) aminotransferase, producing an increase in Gaba concentrations in the brain. It may prove to be an important drug in the treatment of refractory epilepsy, but would be payed attention to behavioural changes noted in association with vigabatrin treatment. Behaviour disturbances, as psychosis, associated to vigabatrin are ben described in adult patients, while are uncommon in childhood. We report a case of acute psychosis occurred in a child in treatment with vigabatrin.
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