These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Differential effects of a hydrophobic tripeptide on human immunodeficiency virus type 1 (HIV-1)-induced syncytium formation and viral infectivity.
    Author: Konopka K, Pretzer E, Düzgünes N.
    Journal: Biochem Biophys Res Commun; 1995 Mar 08; 208(1):75-81. PubMed ID: 7887968.
    Abstract:
    The synthetic hydrophobic peptide, Z-D-Phe-L-Phe-Gly, was shown previously to inhibit the infectivity of paramyxoviruses and the fusion of Sendai virus with liposomes. We examined the ability of this peptide to inhibit HIV-1 infectivity in A3.01, Sup-T1, and H9 cells and syncytium formation between these cells and chronically infected H9 cells. Although the peptide inhibited syncytium formation in a dose-dependent manner, its effect on virus infectivity was very limited. Our results suggest that the mechanisms of interaction of the HIV-1 envelope glycoprotein gp120/gp41 with the target cell membrane leading to membrane fusion may be different in cell-cell and virus-cell fusion.
    [Abstract] [Full Text] [Related] [New Search]