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  • Title: Cutaneous infiltration in T-cell prolymphocytic leukaemia.
    Author: Mallett RB, Matutes E, Catovsky D, Maclennan K, Mortimer PS, Holden CA.
    Journal: Br J Dermatol; 1995 Feb; 132(2):263-6. PubMed ID: 7888364.
    Abstract:
    T-cell prolymphocytic leukaemia (T-PLL) is an aggressive leukaemia accounting for over 30% of all mature T-cell malignancies. We describe the clinical manifestations and histology of cutaneous involvement in a series of 92 patients with T-PLL. Of the 92 patients, 26 (28%) had cutaneous involvement, and in 23 this was present at the time of the diagnosis of the leukaemia. Skin manifestations included a diffuse infiltrated erythema, infiltration localized to the face and ears, nodules and erythroderma. Histology showed a perivascular and periappendageal dermal infiltrate of lymphoid cells with the morphology of prolymphocytes. An early skin biopsy in these patients should help to reveal the underlying diagnosis.
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