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  • Title: Ancient origin of RNA editing in kinetoplastid protozoa.
    Author: Simpson L, Maslov DA.
    Journal: Curr Opin Genet Dev; 1994 Dec; 4(6):887-94. PubMed ID: 7888760.
    Abstract:
    A rooted phylogenetic tree of the kinetoplastid protozoa has been constructed that, together with a comparative analysis of editing of several genes, leads to the surprising conclusion that extensive or pan-editing with multiple overlapping guide RNAs is more ancient than 5'-editing. The mechanism of editing is still uncertain, but multiple ribonucleoprotein complexes have been identified that contain components of the enzymatic machinery.
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