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  • Title: Identification of prodrug, active drug, and metabolites in an ADEPT clinical study.
    Author: Springer CJ, Poon GK, Sharma SK, Bagshawe KD.
    Journal: Cell Biophys; 1993; 22(1-3):9-26. PubMed ID: 7889545.
    Abstract:
    Antibody-directed enzyme prodrug therapy (ADEPT) involves two phases. The first is an antibody-enzyme conjugate that localizes to tumor. The second phase is a prodrug that is administered when the enzyme-conjugate has cleared from blood and other nontumor tissues. In the pilot-scale clinical trial, the prodrug has been measured--in the plasma of patients, by liquid chromatography (HPLC) and by liquid chromatography-mass spectrometry (LC-MS). Active drug has been detected and metabolites identified. An indirect measurement of enzyme-conjugate in the plasma of patients has also been developed.
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