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  • Title: In vitro activity of biapenem against beta-lactamase producing Enterobacteriaceae.
    Author: Alonso R, Fernández-Aranguiz A, Colom K, Morla A, Suinaga E, Umaran A, Cisterna R.
    Journal: Eur J Clin Microbiol Infect Dis; 1994 Oct; 13(10):820-2. PubMed ID: 7889951.
    Abstract:
    The activity of biapenem was compared with that of imipenem and cefotaxime against 108 strains of beta-lactamase producing Enterobacteriaceae. Biapenem and imipenem were very active, inhibiting 90% of the strains at a concentration of 0.5 microgram/ml. Both carbapenems were very active against plasmidic beta-lactamase producers, with MIC90s below 1 microgram/ml. However, the MIC90 of biapenem for cephalosporinase producers was 1 microgram/ml. Against strains producing extended-spectrum beta-lactamases, biapenem exhibited better activity against TEM-type producers (MIC90 0.25 microgram/ml) than against SHV-type producers (MIC90 0.5 microgram/ml). Overall, the in vitro antibacterial activity of biapenem is similar to that of imipenem.
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