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  • Title: Combination amphotericin B-rifampin therapy for pulmonary aspergillosis in a leukemic patient.
    Author: Ribner B, Keusch GT, Hanna BA, Perloff M.
    Journal: Chest; 1976 Nov; 70(5):681-3. PubMed ID: 789031.
    Abstract:
    Pulmonary aspergillosis developed in a 62-year-old man with acute myelogenous leukemia. Therapy with amphotericin B and 5-fluorocytosine was begun. Synergy between amphotericin B and rifampin was demonstrated in vitro, and therapy with firampin replaced 5-fluorocytosine. Progressive clearing of the pulmonary lesion ensued, suggesting in vivo efficacy as well. Further studies of patients utilizing this regimen are warranted.
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