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  • Title: Localization of basic fibroblast growth factor in bovine adrenal chromaffin cells.
    Author: Bieger SC, Henkel AW, Unsicker K.
    Journal: J Neurochem; 1995 Apr; 64(4):1521-7. PubMed ID: 7891078.
    Abstract:
    We have investigated basic fibroblast growth factor (FGF-2) localization in and release from isolated bovine adrenal chromaffin cells. In contrast to previous reports, we found no evidence of fibroblast growth factor (FGF) storage in catecholamine-containing chromaffin granules. Subcellular fractionation studies did not show enrichment of FGF-2 immunoreactivity in granules, and cholinergic stimulation failed to release FGF-2 into the medium. Our results suggest that adrenal chromaffin cells resemble other FGF-2-synthesizing cell types with respect to FGF storage and secretion.
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