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  • Title: Incorporation of lactate measurement in multi-spin-echo proton spectroscopic imaging.
    Author: Duyn JH, Frank JA, Moonen CT.
    Journal: Magn Reson Med; 1995 Jan; 33(1):101-7. PubMed ID: 7891522.
    Abstract:
    An improved multi-slice, multi-spin-echo proton spectroscopic imaging method for human brain is presented. The technique allows the reconstruction of lactate images, along with choline plus creatine, N-acetylaspartate, and lipid images from one single data set processed in three separate ways. The discrimination between resonances of lipid protons and lactate methyl protons is based on homonuclear spin-spin coupling. The reliability of the separation of the lipid and lactate contribution depends on the T2 of the lipid resonances. Measurements were performed on a standard 1.5 Tesla clinical scanner on healthy volunteers and a patient with high grade CNS lymphoma, demonstrating the ability to obtain high quality metabolite maps within 11 min.
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