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  • Title: Alloantigen priming induces a state of unresponsiveness in human umbilical cord blood T cells.
    Author: Risdon G, Gaddy J, Horie M, Broxmeyer HE.
    Journal: Proc Natl Acad Sci U S A; 1995 Mar 14; 92(6):2413-7. PubMed ID: 7892281.
    Abstract:
    Induction of alloreactivity in human adult and umbilical cord blood T cells was evaluated in mixed leukocyte culture by exposure to an allogeneic lymphoblastoid line that expresses known costimulatory molecules. Initial exposure to alloantigen-presenting cells (allo-APC) induced strong proliferative responses in both adult and cord blood T cells. However, in contrast to adult T cells, cord blood T cells exhibited little proliferation after restimulation with donor APC. Primed cord blood T cells could respond to interleukin 2 (IL-2), but unresponsiveness to alloantigen was not overcome by addition of exogenous IL-2. Unresponsiveness was long-lasting and appeared to be maintained by a combination of induction of anergy and activity of CD8+ suppressor cells. This information may contribute to use of human cord blood as an allogeneic source of transplantable stem cells.
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