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  • Title: [The solubility and bioequivalence of silymarin preparations].
    Author: Schulz HU, Schürer M, Krumbiegel G, Wächter W, Weyhenmeyer R, Seidel G.
    Journal: Arzneimittelforschung; 1995 Jan; 45(1):61-4. PubMed ID: 7893272.
    Abstract:
    Seven silymarin products (pharmacies only), two of them with two batches each, were analysed for their ingredients, in particular silibinin (CAS 22888-70-6) and tested in vitro for their liberation of active agents. Founded on the results of these tests three products were checked for bioequivalence. Therefore, a typical phase I 3 fold crossover study was performed showing one product (Legalon) to be qualified by an approx. 2 fold higher silibinin availability compared to the two other preparations.
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