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  • Title: Inhibitory effect of Mg2+ on the protonophoric activity of palmitic acid.
    Author: Shinohara Y, Unami A, Teshima M, Nishida H, van Dam K, Terada H.
    Journal: Biochim Biophys Acta; 1995 Mar 14; 1228(2-3):229-234. PubMed ID: 7893729.
    Abstract:
    To discriminate whether fatty acids are uncouplers that cause acceleration of State-4 respiration, associated with a decrease in the protonmotive force, or decouplers that increase respiration without associated decrease in the protonmotive force, we examined the effect of palmitate on functions of rat-liver mitochondria under various conditions. We found that palmitate itself increases State-4 respiration, releases oligomycin-inhibited State-3 respiration, inhibits ATP synthesis and ATP<->Pi exchange reaction, and increases H+ permeability in mitochondrial and model bilayer phospholipid membranes. Thus, palmitate is a classical uncoupler of oxidative phosphorylation. However, these effects were inhibited by Mg2+, due to rapid formation of a stable complex between palmitate and Mg2+.
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